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Description | Flubromazepam is a synthetic benzodiazepine that has been increasingly used in laboratory experiments. It is a central nervous system depressant that is known for its sedative, anxiolytic, anticonvulsant, and muscle relaxant properties. Flubromazepam has been used to study the effects of benzodiazepines on behavior, memory, and cognition in laboratory animals. In addition, it has been used to investigate the pharmacokinetics of benzodiazepines in humans. |
Synthesis Method | Flubromazepam is synthesized from 7-bromo-5-chloro-1-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. This synthesis method involves the reaction of 7-bromo-5-chloro-1-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one with an alkylating agent such as dimethyl sulfate or ethyl chloroformate. The reaction produces the desired product, flubromazepam. |
Scientific Research Application | Flubromazepam has been used in a number of scientific research studies. It has been used to investigate the pharmacokinetics of benzodiazepines in humans. It has also been used to study the effects of benzodiazepines on behavior, memory, and cognition in laboratory animals. In addition, it has been used to investigate the mechanism of action of benzodiazepines on the central nervous system. |
Mechanism of Action | Flubromazepam binds to the gamma-aminobutyric acid (GABA) receptor, which is a type of receptor that is involved in the regulation of neuronal excitability. It binds to the GABA receptor and increases the frequency of chloride ion channel opening. This increases the inhibitory effect of GABA on the neuron, resulting in sedation, anxiolysis, and muscle relaxation. |
Biochemical and Physiological Effects | Flubromazepam has a number of biochemical and physiological effects on the body. It acts as a sedative, anxiolytic, anticonvulsant, and muscle relaxant. It also produces an increase in heart rate, blood pressure, and respiration rate. In addition, it produces changes in the levels of neurotransmitters such as serotonin, dopamine, and norepinephrine. |
Advantages and Limitations for Lab Experiments | Flubromazepam has a number of advantages and limitations for laboratory experiments. Its advantages include its sedative, anxiolytic, anticonvulsant, and muscle relaxant properties. In addition, it is relatively safe and has minimal side effects. Its limitations include its short half-life, which limits its use in long-term studies. In addition, it can cause tolerance and physical dependence in some individuals. |
Future Directions | There are a number of potential future directions for research on flubromazepam. These include further studies on its pharmacokinetics, mechanism of action, and biochemical and physiological effects. In addition, further research could be conducted on its potential therapeutic applications, such as its use as an anxiolytic or anticonvulsant. Other potential areas of research include its potential use in the treatment of insomnia and its potential use as an adjunct to other medications. Finally, further research could be conducted on its potential adverse effects and interactions with other drugs. |
CAS RN | 2647-50-9 |
Product Name | Flubromazepam |
Molecular Formula | C15H10BrFN2O |
Molecular Weight | 333.15 g/mol |
IUPAC Name | 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one |
InChI | InChI=1S/C15H10BrFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) |
InChI Key | ZRKDDZBVSZLOFS-UHFFFAOYSA-N |
SMILES | C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=C3F |
Canonical SMILES | C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=C3F |
Other CAS RN | 2647-50-9 |
Synonyms | 7-bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one |
Origin of Product | United States |
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